{"id":2703,"date":"2023-03-20T10:35:41","date_gmt":"2023-03-20T09:35:41","guid":{"rendered":"https:\/\/cohortecantabria.com\/?page_id=2703"},"modified":"2026-08-06T09:41:44","modified_gmt":"2026-08-06T07:41:44","slug":"proyectos","status":"publish","type":"page","link":"https:\/\/cohortecantabria.com\/en\/proyectos\/","title":{"rendered":"Research Projects"},"content":{"rendered":"<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-getwid-button-group\"><div class=\"wp-block-getwid-button-group__wrapper has-alignment-center\">\n<div class=\"wp-block-button is-style-circular\" id=\"BOTONESACTIVIDADCIENTIFICA\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/cohortecantabria.com\/en\/proyectos\/\">Research Projects<\/a><\/div>\n\n\n\n<div class=\"wp-block-button is-style-circular\" id=\"BOTONESACTIVIDADCIENTIFICA\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/cohortecantabria.com\/en\/https:\/\/cohortecantabria.com\/https:\/\/cohortecantabria.com\/proyectos-financiados\/\">Funded Projects<\/a><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-getwid-button-group\"><div class=\"wp-block-getwid-button-group__wrapper has-alignment-center\">\n<div class=\"wp-block-button is-style-circular\" id=\"BOTONESACTIVIDADCIENTIFICA\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/cohortecantabria.com\/en\/publicaciones\/\">Publications<\/a><\/div>\n\n\n\n<div class=\"wp-block-button is-style-circular\" id=\"BOTONESACTIVIDADCIENTIFICA\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/cohortecantabria.com\/en\/comunicaciones\/\">Communications<\/a><\/div>\n\n\n\n<div class=\"wp-block-button is-style-circular\" id=\"BOTONESACTIVIDADCIENTIFICA\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/cohortecantabria.com\/en\/actividad-cientifica\/otros\/\" style=\"border-style:none;border-width:0px;border-radius:0px\">Others<\/a><\/div>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-cover alignfull is-light wp-duotone-unset-1\" style=\"min-height:172px;aspect-ratio:unset;\"><img fetchpriority=\"high\" decoding=\"async\" width=\"4216\" height=\"3456\" data-attachment-id=\"6067\" data-permalink=\"https:\/\/cohortecantabria.com\/en\/proyectos\/interior_8-1\/\" data-orig-file=\"https:\/\/cohortecantabria.com\/wp-content\/uploads\/2023\/10\/Interior_8-1.jpg\" data-orig-size=\"4216,3456\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;1.8&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;Canon EOS 600D&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;1697028408&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;50&quot;,&quot;iso&quot;:&quot;100&quot;,&quot;shutter_speed&quot;:&quot;0.016666666666667&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Interior_8-1\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/cohortecantabria.com\/wp-content\/uploads\/2023\/10\/Interior_8-1-1024x839.jpg\" class=\"wp-block-cover__image-background wp-image-6067\" alt=\"\" src=\"https:\/\/cohortecantabria.com\/wp-content\/uploads\/2023\/10\/Interior_8-1.jpg\" style=\"object-position:54% 14%\" data-object-fit=\"cover\" data-object-position=\"54% 14%\" srcset=\"https:\/\/cohortecantabria.com\/wp-content\/uploads\/2023\/10\/Interior_8-1.jpg 4216w, https:\/\/cohortecantabria.com\/wp-content\/uploads\/2023\/10\/Interior_8-1-300x246.jpg 300w, https:\/\/cohortecantabria.com\/wp-content\/uploads\/2023\/10\/Interior_8-1-1024x839.jpg 1024w, https:\/\/cohortecantabria.com\/wp-content\/uploads\/2023\/10\/Interior_8-1-768x630.jpg 768w, https:\/\/cohortecantabria.com\/wp-content\/uploads\/2023\/10\/Interior_8-1-1536x1259.jpg 1536w, https:\/\/cohortecantabria.com\/wp-content\/uploads\/2023\/10\/Interior_8-1-2048x1679.jpg 2048w, https:\/\/cohortecantabria.com\/wp-content\/uploads\/2023\/10\/Interior_8-1-1200x984.jpg 1200w, https:\/\/cohortecantabria.com\/wp-content\/uploads\/2023\/10\/Interior_8-1-1568x1285.jpg 1568w\" sizes=\"(max-width: 4216px) 100vw, 4216px\" \/><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim-10 has-background-dim\" style=\"background-color:#FFF\"><\/span><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<p class=\"has-text-align-center has-background-color has-text-color has-huge-font-size coblocks-animate wp-block-paragraph\" id=\"PROYECTOS-DE-INVESTIGACION\" style=\"font-size:33px\" data-coblocks-animation=\"fadeIn\"><strong>RESEARCH PROJECTS<\/strong><\/p>\n<\/div><\/div>\n\n\n\n<style>\np,div{\n  text-align: justify;\n}\n<\/style>\n\n\n\n<div style=\"text-align: justify;\">\nBelow are all the research projects that are using data and samples from Cantabria Cohort:\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-primary-color has-alpha-channel-opacity has-primary-background-color has-background is-style-dots\"\/>\n\n\n\n<div>\n<b>Title:<\/b> Difficult-to-Treat Depression: Study of Gene and Protein Biomarkers Associated with Clinical Response to Ketamine and Electroconvulsive Therapy <br>\n\n<b>Aim:<\/b> To improve understanding of the neurobiological mechanisms underlying difficult-to-treat depression (DTD), with a particular focus on the role of BDNF and GRIN2B in both the pathogenesis of the disorder and the response to advanced treatments.  <br>\n\n<div class=\"exp-col-content-holder\"><a class=\"expand-cnt-link\" href=\"#\">Details and scientific description<\/a>\n\n<div class=\"hidden-content\">\n<p class=\"hiddenContentp\">\n\n<br><b>Conducting entity:<\/b> HUMV-IDIVAL <br>\n\n<b>Principal investigator:<\/b> Dr Marcos G\u00f3mez Revuelta<br><br>\n\n<\/p><div style=\"text-align: justify;\">\nDifficult-to-treat depression (DTD) is a complex condition for which there is still limited understanding, particularly regarding its underlying neurobiological mechanisms and the factors that influence treatment response. This project will focus on investigating the role of two molecular markers, BDNF and GRIN2B, which are involved in key brain processes such as neuronal plasticity and neurotransmission. <\/div>\n\n<p><\/p><div style=\"text-align: justify;\">The study will analyse these biomarkers in patients with DTD, evaluating their association with both the development of the disorder and the response to advanced therapies, including electroconvulsive therapy (ECT) and esketamine treatment. The findings will also be compared with those obtained from healthy volunteers participating in the Cantabria Cohort, who will serve as the control group, enabling the identification of relevant biological differences between healthy individuals and patients. \n<\/div>\n\n<p><\/p><div style=\"text-align: justify;\">This approach will contribute to a better understanding of the biological mechanisms involved in difficult-to-treat depression and may help identify new biomarkers to support the selection of more effective and personalised treatment strategies.\n<\/div><br>\n<p><\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-primary-color has-alpha-channel-opacity has-primary-background-color has-background is-style-dots\"\/>\n\n\n\n<div>\n<b>Title:<\/b> Inflammatory and Metabolic Markers in Patients with Difficult-to-Treat Depression Associated with Obesity<br>\n\n<b>Aim:<\/b> To improve understanding of the biological mechanisms involved in major depressive disorder, with particular emphasis on the role of obesity and inflammation in the severity and progression of depressive symptoms.  <br>\n\n<div class=\"exp-col-content-holder\"><a class=\"expand-cnt-link\" href=\"#\">Details and scientific description<\/a>\n\n<div class=\"hidden-content\">\n<p class=\"hiddenContentp\">\n\n<br><b>Conducting entity:<\/b> HUMV-IDIVAL, IBBTEC<br>\n\n<b>Investigadores principales:<\/b> Dr Fuencisla Pilar Cu\u00e9llar and Dr Marcos G\u00f3mez Revuelta<br><br>\n\n<\/p><div style=\"text-align: justify;\">\nMajor depressive disorder is one of the most common illnesses worldwide and a leading cause of disability, with a substantial impact on patients' quality of life. The aim of this project is to identify metabolic, inflammatory, and molecular biomarkers associated with the severity of depressive symptoms.<\/div>\n<p><\/p><div style=\"text-align: justify;\">To achieve this, serum samples from healthy volunteers participating in the Cantabria Cohort will be analysed as a control group and compared with samples from patients with difficult-to-treat depression (DTD), distinguishing between those with and without obesity. This approach will make it possible to assess whether biological differences exist between the groups and will contribute to a better understanding of the mechanisms underlying major depressive disorder.\n\n<\/div><br>\n<p><\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-primary-color has-alpha-channel-opacity has-primary-background-color has-background is-style-dots\"\/>\n\n\n\n<div>\n<b>Title:<\/b> Prevalence of Chronic Kidney Disease Based on Estimated Glomerular Filtration Rate (eGFR) and Its Impact on Cardiovascular Risk Stratification and the Adequacy of Lipid Control According to the 2025 ESC\/EAS Guidelines on Dyslipidaemias: Findings from the Cantabria Cohort<br>\n\n<b>Aim:<\/b> To improve understanding of how chronic kidney disease influences the risk of developing cardiovascular disease and to assess whether individuals at higher cardiovascular risk receive appropriate management of their cholesterol and other blood lipid levels.   <br>\n\n<div class=\"exp-col-content-holder\"><a class=\"expand-cnt-link\" href=\"#\">Details and scientific description<\/a>\n\n<div class=\"hidden-content\">\n<p class=\"hiddenContentp\">\n\n<br><b>Conducting entity:<\/b> Department of Nephrology, Carmen y Severo Ochoa Hospital<br>\n\n<b>Investigadores principales:<\/b> Dr Jaime Maz\u00f3n Ruiz and Dr Gema Fern\u00e1ndez Fresnedo<br><br>\n\n<\/p><div style=\"text-align: justify;\">\nChronic kidney disease is a common health condition that significantly increases the risk of cardiovascular disease, even before kidney-related symptoms become apparent. This project will use laboratory data from Cantabria Cohort participants to estimate the prevalence of chronic kidney disease within the cohort. Clinical, sociodemographic, and laboratory data will then be integrated to classify participants according to their cardiovascular risk, following the 2025 ESC\/EAS Guidelines on Dyslipidaemias. The study will also evaluate the extent to which participants achieve recommended cholesterol and triglyceride targets, as well as the appropriateness of the lipid-lowering treatment they receive. The findings will help identify opportunities to improve cardiovascular disease prevention, particularly among people with chronic kidney disease, and will contribute to the development of more effective strategies to reduce the burden of cardiovascular disease in the population.\n<\/div><br>\n<p><\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-primary-color has-alpha-channel-opacity has-primary-background-color has-background is-style-dots\"\/>\n\n\n\n<div>\n<b>Title:<\/b> Preclinical Cognitive Risk Profiles and Healthy Longevity: Integrating Lifestyle, Family History, and APOE \u03b54 Genotype in the Cantabria Cohort (ALBA-APOE)<br>\n\n<b>Aim:<\/b> To improve our understanding of how specific genetic factors influence cognitive performance before the onset of Alzheimer's disease symptoms, and to determine the extent to which healthy lifestyle habits, such as physical activity and higher perceived well-being, may help protect brain function. <br>\n\n<div class=\"exp-col-content-holder\"><a class=\"expand-cnt-link\" href=\"#\">Details and scientific description<\/a>\n\n<div class=\"hidden-content\">\n<p class=\"hiddenContentp\">\n\n<br><b>Conducting entity:<\/b> Antonio de Nebrija University<br>\n\n<b>Principal investigator:<\/b> Ana Isabel Beltr\u00e1n Velasco<br><br>\n\n<\/p><div style=\"text-align: justify;\">\nAlzheimer's disease begins to develop many years before the first symptoms appear, and both genetic factors and lifestyle habits play an important role in this process. Using a total of 400 DNA samples from the Cantabria Cohort, this study will analyse genetic variants associated with the risk of developing Alzheimer's disease, with particular focus on the APOE gene, one of the main genetic factors linked to an increased likelihood of developing the disease. In addition, the project will use information collected through the Cantabria Cohort, including data on family history, health behaviours, perceived well-being, and cognitive performance from approximately 1,600 participants. Integrating genetic information with cognitive and lifestyle data will provide a better understanding of how these factors interact, helping to identify both higher-risk profiles and protective factors. The findings will contribute to the development of more personalised prevention strategies aimed at promoting healthy brain ageing.\n<\/div><br>\n<p><\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-primary-color has-alpha-channel-opacity has-primary-background-color has-background is-style-dots\"\/>\n\n\n\n<div>\n<b>Title:<\/b> Impact of Family History of Alzheimer\u2019s Disease on Cognitive and Functional Profile in Adults Without Clinical Diagnosis: Analysis in the Cantabria Cohort<br>\n\n<b>Aim:<\/b> To characterize, in cognitively intact adults with and without a family history of Alzheimer\u2019s disease, differences in cognitive performance, and to investigate how habitual physical activity and subjective health perception modulate this association.<br>\n\n<div class=\"exp-col-content-holder\"><a class=\"expand-cnt-link\" href=\"#\">Details and scientific description<\/a>\n\n<div class=\"hidden-content\">\n<p class=\"hiddenContentp\">\n\n<br><b>Conducting entity:<\/b> Antonio de Nebrija University<br>\n\n<b>Principal investigator:<\/b> Ana Isabel Beltr\u00e1n Velasco<br><br>\n\n<div style=\"text-align: justify;\">\nThe study investigates how a family history of Alzheimer\u2019s disease and lifestyle habits may influence the cognitive functioning of adults who do not yet show memory problems or cognitive impairment. Using existing cohort data, cognitive performance, physical activity habits, and perceived health will be analyzed in more than 1,600 individuals over the age of 40.\n\nThe aim is to better understand which early signals may appear many years before diagnosis and how lifestyle factors\u2014such as physical exercise and a positive perception of one\u2019s own health\u2014may play a protective role. This information will help advance early risk detection and support the design of accessible preventive strategies for the general population.\n<\/div><br>\n<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-alpha-channel-opacity has-background is-style-dots\" style=\"background-color:#2817a3;color:#2817a3\"\/>\n\n\n\n<div>\n<b>Title:<\/b> Preventing Dementia and Stroke: Analysis of Modifiable Risk Factors in the Population of Cantabria<br>\n\n<b>Aim:<\/b> Calculate the frequency of the main vascular and dementia risk factors in Cantabria Cohort and incorporate this information into the activities of the JADE Health initiative.<br>\n\n<div class=\"exp-col-content-holder\"><a class=\"expand-cnt-link\" href=\"#\">Details and scientific description<\/a>\n\n<div class=\"hidden-content\">\n<p class=\"hiddenContentp\">\n\n<br><b>Conducting entity:<\/b> IDIVAL<br>\n\n<b>Principal investigator:<\/b> Dra. Carmen Lage Mart\u00ednez<br><br>\n\n<b>Funding organization:<\/b> EU4Health Programme, funded by the European Union<br><br>\n\n<div style=\"text-align: justify;\">\nThis is a descriptive study based on data collected by Cantabria Cohort to explore the main modifiable risk factors for neurodegenerative and neurovascular diseases in our community. This project is part of the European initiative JADE Health, in which IDIVAL is a participant. The initiative aims to investigate community- and country-specific risk factors, estimate the number of potentially preventable cases, and analyze the existing surveillance systems for these risk factors in each country.\n<\/div><br>\n<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-alpha-channel-opacity has-background is-style-dots\" style=\"background-color:#2817a3;color:#2817a3\"\/>\n\n\n\n<div>\n<b>Title:<\/b> Impact of Circadian Disruption on Cardiometabolic Health and the Development of Chronic Diseases: Exploring the Role of Inflammation<br>\n\n<b>Aim:<\/b> To evaluate the impact of disruption in the sleep-wake cycle on the development of chronic systemic inflammation, a cardiometabolic risk profile, and chronic diseases such as type 2 diabetes, depression, and cardiovascular diseases.<br>\n\n<div class=\"exp-col-content-holder\"><a class=\"expand-cnt-link\" href=\"#\">Details and scientific description<\/a>\n\n<div class=\"hidden-content\">\n<p class=\"hiddenContentp\">\n\n<br><b>Conducting entity:<\/b> IDIVAL \u2013 Cantabria Cohort<br>\n\n<b>Investigadores principales:<\/b> Dr. Trinidad Dierssen Sotos and Dr. Juan Irure Ventura<br><br>\n\n<b>Funding organization:<\/b> Instituto de Salud Carlos III (AES 2024)<br><br>\n\n<\/p><div style=\"text-align: justify;\">\nStudies examining the relationship between circadian disruption (CD) and the development of chronic diseases have yielded inconsistent results. It has been suggested that chronic systemic inflammation (CSI) may act as a mediator in this association, although this hypothesis has not been sufficiently tested, nor has the potential modifying effect of factors such as sex or chronotype been thoroughly explored. This study aims to assess the impact of CD on CSI, cardiometabolic risk profile, and the onset of chronic diseases, within the framework of a prospective cohort study involving 25,000 participants from the Cantabria Cohort (CoCAN group). CD will be assessed using questionnaires covering work shifts, sleep patterns, chronotype, meal timing, and exposure to artificial light at night (ALAN). CSI will be measured using two indices derived from the complete blood count, while the cardiometabolic profile will be evaluated at baseline and after four years through bioimpedance analysis, lipid profile, HbA1c, and HOMA-IR. The incidence of chronic diseases will be tracked through record linkage and follow-up questionnaires. Additionally, a subgroup of 1,000 participants recruited since January 2023 (CoCIR group) will undergo a more in-depth assessment of CD and CSI. In this subgroup, inflammation indices from the blood count will be validated against circulating profiles of pro- and anti-inflammatory cytokines; the reliability of sleep questionnaires will be assessed using activity trackers, and ALAN questionnaires will be validated with luxometers. Blood pressure will also be measured at the beginning and end of the follow-up period.\n<\/div><br>\n<p><\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-alpha-channel-opacity has-background is-style-dots\" style=\"background-color:#2817a3;color:#2817a3\"\/>\n\n\n\n<div>\n<b>Title:<\/b> Validation of a precision medicine tool based on online cognitive assessment, genetic risk stratification, and blood-based biomarkers for the identification of preclinical Alzheimer's disease.<br>\n\n<b>Aim:<\/b> Improve the prevention and diagnosis of Alzheimer\u2019s disease by integrating precision medicine tools that enable the development of strategies to identify cases in the early stages of the disease.<br>\n\n<div class=\"exp-col-content-holder\"><a class=\"expand-cnt-link\" href=\"#\">Details and scientific description<\/a>\n\n<div class=\"hidden-content\">\n<p class=\"hiddenContentp\">\n\n<br><b>Conducting entity:<\/b> Fundaci\u00f3n CIEN<br>\n\n<b>Principal investigator:<\/b> Dr. Pascual Jes\u00fas S\u00e1nchez Juan<br><br>\n\n<b>Funding organization:<\/b> Instituto de Salud Carlos III, funded by the European NextGenEU funds supporting actions under the Recovery and Resilience Facility.<br><br>\n\n<\/p><div style=\"text-align: justify;\">\nThe SCAP-AD project (Cognitive Screening and Personalized Approach for Alzheimer\u2019s and other Dementias) is a multicenter initiative coordinated by Fundaci\u00f3n CIEN, involving 13 centers across 8 autonomous communities from the DEGESCO consortium. The main objective is to validate a precision medicine tool based on online cognitive assessment, genetic risk stratification, and plasma biomarker analysis for the identification of preclinical Alzheimer\u2019s disease (PMP22\/00022). To achieve this, two large cohorts will be developed in parallel. On one hand, a digital cohort will explore the use of digital biomarkers through online tools in adults over 60 years old. On the other hand, a clinical validation cohort of 2,000 individuals over 60 years of age, without a diagnosis of dementia, will undergo an in-depth assessment including clinical and neuropsychological evaluations, biomarker analysis (CSF and plasma), and magnetic resonance imaging.\n<\/div><br>\n<p><\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-alpha-channel-opacity has-background is-style-dots\" style=\"background-color:#2817a3;color:#2817a3\"\/>\n\n\n\n<div>\n<b>Title:<\/b> Cantabria in shape: A Strategic Project for the Prevention of Obesity and Overweight in the Child Population of Cantabria<br>\n\n<b>Aim:<\/b> Analyze the sociodemographic factors and lifestyle habits of schoolchildren and their caregivers, as well as identify the main determinants of overweight and obesity in the participants of Cantabria Cohort.<br>\n\n<div class=\"exp-col-content-holder\"><a class=\"expand-cnt-link\" href=\"#\">Details and scientific description<\/a>\n\n<div class=\"hidden-content\">\n<p class=\"hiddenContentp\">\n\n<br><b>Conducting entity:<\/b> General Directorate of Public Health through the Public Health Observatory of Cantabria and Cantabria Cohort, Valdecilla Research Institute Foundation (IDIVAL)<br>\n\n<b>Principal investigator:<\/b> Laura Rasines P\u00e9rez<br><br>\n\n\n<div style=\"text-align: justify;\">\nChildhood obesity has serious short-term consequences and predisposes individuals to chronic diseases in adulthood, making early intervention and coordinated efforts between the healthcare, educational, and community sectors urgent. Despite previous efforts, childhood obesity rates in Cantabria have risen, reaching 8.2% in 2022. This situation highlights the need for more effective policies, grounded in scientific evidence and an integrated approach that includes both children and their families. The Directorate General of Public Health, through the Public Health Observatory of Cantabria, in collaboration with Cantabria Cohort-IDIVAL and the Ministry of Education, aims to collect real data on overweight and childhood obesity to design effective preventive strategies for the benefit of society as a whole.\n\nThrough a detailed questionnaire, the goal is to gather comprehensive information on lifestyle habits and demographic characteristics of the population aged 6 to 16 years, allowing for the identification of associations. Additionally, data from Cantabria Cohort, comprising 50,000 volunteers, will be analyzed to determine the factors contributing to excess weight in the population of Cantabria.\n<\/div><br>\n<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-alpha-channel-opacity has-background is-style-dots\" style=\"background-color:#2817a3;color:#2817a3\"\/>\n\n\n\n<div>\n<b>Title:<\/b> Biomonitoring of Persistent Organic Pollutants and Endocrine Disruptors in a Representative Sample of the Population of Cantabria (Cantabria Cohort)<br>\n\n<b>Aim:<\/b> To assess exposure to persistent organic pollutants and endocrine disruptors in participants of Cantabria Cohort and analyze their relationship with demographic factors, lifestyle, and medical history.<br>\n\n\n<div class=\"exp-col-content-holder\"><a class=\"expand-cnt-link\" href=\"#\">Details and scientific description<\/a>\n\n<div class=\"hidden-content\">\n<p class=\"hiddenContentp\">\n\n<br><b>Conducting entity:<\/b> HUMV &#8211; IDIVAL<br>\n\n<b>Principal investigator:<\/b> Mar\u00eda Teresa Garc\u00eda Unzueta, MD, PhD<br>\n\n<b>Funding organization:<\/b> Spanish Ministry of Health<br><br>\n\n\n<div style=\"text-align: justify;\">\nExposure to persistent organic pollutants (POPs) and endocrine disruptors (EDs) poses a significant public health risk. This project aims to assess the exposure of the Cantabrian population to these compounds through biomonitoring of participants in Cantabria Cohort, identifying risk factors and promoting preventive strategies. Researchers have access to a high-resolution mass spectrometry system (Orbitrap 120), enabling reliable analysis of various contaminants such as BPA, phthalates, parabens, and perfluorinated compounds. The results will provide essential information to guide public policies and reduce exposure to these harmful substances.\n<\/div><br>\n<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-alpha-channel-opacity has-background is-style-dots\" style=\"background-color:#2817a3;color:#2817a3\"\/>\n\n\n\n<div>\n<b>Title:<\/b> Prevalence and Risk Factors of Advanced Metabolic Liver Disease in Women with Premature Ovarian Insufficiency<br>\n\n<b>Aim:<\/b> To determine the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) and liver fibrosis in women with premature ovarian insufficiency (POI) or diminished ovarian reserve (DOR).<br>\n\n\n<div class=\"exp-col-content-holder\"><a class=\"expand-cnt-link\" href=\"#\">Details and scientific description<\/a>\n\n<div class=\"hidden-content\">\n<p class=\"hiddenContentp\">\n\n<br><b>Conducting entity:<\/b> HUMV &#8211; IDIVAL<br>\n\n<b>Principal investigator:<\/b> Mar\u00eda Teresa Arias Loste, MD, PhD<br><br>\n\n<div style=\"text-align: justify;\">\nThere are no direct epidemiological studies linking premature ovarian insufficiency (POI) with metabolic dysfunction-associated steatotic liver disease (MASLD). However, some findings suggest a possible connection between these conditions. Women with POI exhibit metabolic alterations such as insulin resistance, dyslipidemia, and elevated liver enzymes, which could contribute to the development of MASLD. Additionally, POI has been associated with a higher risk of autoimmune diseases, some of which may impact liver function.\n<br>\nOn the other hand, MASLD has been associated with polycystic ovary syndrome (PCOS), another endocrine condition that shares mechanisms such as insulin resistance and hyperandrogenism. Although the relationship between POI and MASLD has not been specifically studied, their common metabolic and autoimmune alterations suggest a potential link between the two. Further research is needed to determine whether women with POI have a higher risk of developing MASLD or vice versa.\n<br>\nThe main objective of this study is to determine the prevalence of MASLD and liver fibrosis in women with POI or diminished ovarian reserve (DOR). Additionally, the study aims to evaluate the metabolic, hormonal, and autoimmune risk factors associated with MASLD in this population, as well as compare the metabolic and hepatic characteristics between women with and without POI\/DOR. Finally, the study seeks to identify potential causal or correlative associations between ovarian alterations and liver fibrosis, which could contribute to a better understanding of the shared pathophysiological mechanisms.\n<\/div><br>\n<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-alpha-channel-opacity has-background is-style-dots\" style=\"background-color:#2817a3;color:#2817a3\"\/>\n\n\n\n<div>\n<b>Title:<\/b> Genetic Biomarkers of the Cannabinoid System in Alcohol Use Disorder<br>\n\n<b>Aim:<\/b> To study the association of genetic biomarkers of the cannabinoid system in patients with alcohol use disorder.<br>\n\n\n<div class=\"exp-col-content-holder\"><a class=\"expand-cnt-link\" href=\"#\">Details and scientific description<\/a>\n\n<div class=\"hidden-content\">\n<p class=\"hiddenContentp\">\n\n<br><b>Conducting entity:<\/b> ISABIAL &#8211; Universidad Miguel Hern\u00e1ndez (UMH)<br>\n\n<b>Principal investigator:<\/b> Dr. Jorge Manzanares<br>\n\n<b>Funding organization:<\/b> Instituto de Salud Carlos III<br><br>\n\n<div style=\"text-align: justify;\">\nThe development of Alcohol Use Disorder (AUD) is influenced by multiple bio-psycho-social factors. Genetic variability explains part of the individual differences in the predisposition to develop AUD. Despite the existence of various studies focusing on genetic variants in different genes encoding proteins involved in the cannabinoid system, there is no clear evidence of their implications in alcohol use disorder. Therefore, the objective of this study is to delve deeper into this topic and obtain consistent results that will help improve the management of this disorder, thereby enhancing the quality of life of these patients.\n<br>\nThe working hypothesis suggests that the proportion of genetic variants present in the cannabinoid system in the population with Alcohol Use Disorder (AUD) is different from the proportion of these same variants in the healthy population. To test this hypothesis, an analytical cross-sectional study is proposed, where the independent variable is the presence\/absence of genetic variants in the CNR1, CNR2, GPR55, and FAAH genes, and the dependent variable is the development\/no development of AUD.\n<\/div><br>\n<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-alpha-channel-opacity has-background is-style-dots\" style=\"background-color:#2817a3;color:#2817a3\"\/>\n\n\n\n<div>\n<b>Title:<\/b> ImpactT2D: A Genomic Strategy to Implement Precision Medicine in Type 2 Diabetes<br>\n\n<b>Aim:<\/b> Develop genomic tools to personalize type 2 diabetes treatment by grouping patients based on genetic profiles and treatment responses, using data from Cantabria Cohort and whole genome analyses.<br>\n\n\n<div class=\"exp-col-content-holder\"><a class=\"expand-cnt-link\" href=\"#\">Details and scientific description<\/a>\n\n<div class=\"hidden-content\">\n<p class=\"hiddenContentp\">\n\n<br><b>Conducting entity:<\/b> Centre for Genomic Regulation (CRG)<br>\n\n<b>Principal investigator:<\/b> Dr. Jorge Ferrer<br>\n\n<b>Funding organization:<\/b> Instituto de Salud Carlos III<br><br>\n\n\n<div style=\"text-align: justify;\">\nWhole genome sequences are becoming more accessible, but further studies are needed to prove their usefulness in common diseases like type 2 diabetes (T2D). T2D affects about 14% of the Spanish adult population, is a leading cause of mortality and healthcare costs, and is highly heterogeneous but lacks markers for personalized treatment decisions.\n<br>\nLos scores de riesgo polig\u00e9nico (PRS) tienen potencial para discriminar diferentes mecanismos de riesgo para DT2. Por otra parte, un peque\u00f1o conjunto de pacientes alberga mutaciones codificantes capaces de guiar decisiones cl\u00ednicas. El estudio DecodeDiabetes ha identificado mutaciones no codificantes compartidas por pacientes con diabetes monog\u00e9nicas y DT2. ImpactT2D desplegar\u00e1 una estrategia para demostrar la aplicabilidad cl\u00ednica de la informaci\u00f3n gen\u00f3mica en DT2. Con este fin, obtendr\u00e1 genomas completos de una cohorte singular de 1000 pacientes con un subfenotipo DT2 que maximiza la carga gen\u00e9tica. Definir\u00e1 PRS particionados y variantes raras causales, y utilizar\u00e1 herramientas de IA para desarrollar modelos de estratificaci\u00f3n. Validar\u00e1 estos modelos en pacientes con criterios fenot\u00edpicos m\u00e1s amplios, y desarrollar\u00e1 mecanismos para implementar estos conocimientos en el sistema de salud.\n<br>\nImpactT2D aligns with precision medicine and genomic initiatives for T2D in Spanish and international healthcare centers. It leverages a network of primary care providers, clinical researchers, relevant clinical and genomic cohorts, and multidisciplinary expertise in AI, clinical trials, genomics, and genetics, aiming to deliver transformative insights for precision medicine in T2D.\n<\/div><br>\n<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-alpha-channel-opacity has-background is-style-dots\" style=\"background-color:#2817a3;color:#2817a3\"\/>\n\n\n\n<div>\n<b>Title:<\/b> Technical validation by Valdecilla Biobank of the technology developed by 300K Solutions SL for the stabilization and preservation of biological samples at room temperature as an alternative to ultra-freezing.<br>\n\n<b>Aim:<\/b> Exploring lyophilization as an alternative to ultra-freezing (-80\u00b0C) for preserving plasma samples from 40 participants of Cantabria Cohort<br>\n\n\n<div class=\"exp-col-content-holder\"><a class=\"expand-cnt-link\" href=\"#\">Details and scientific description<\/a>\n\n<div class=\"hidden-content\">\n<p class=\"hiddenContentp\">\n\n<br><b>Conducting entity:<\/b> 300K Solutions S.L.<br>\n\n<b>Principal investigator:<\/b> Marta Mart\u00edn Ayuso<br><br>\n\n\n<div style=\"text-align: justify;\">\nOne of the alternatives to freezing as a more sustainable method for preserving biological samples stored in biobanks is lyophilization, a dehydration methodology for biological samples that allows their maintenance at Room Temperature (RT) for long periods of time. 300K Solutions S.L. has developed proprietary technology that provides biobanks with a tool to stabilize dry samples, combining precision lyophilization technology with protective reagents for the sample and vial formats that ensure traceability in biobanks.\n<br>\nThe present study aims to compare the quality of lyophilized plasma samples with fresh and frozen samples. The objective is to validate lyophilization as a viable storage format while maintaining the quality of biological samples at RT. To achieve this, two quantifiable circulating proteins in plasma, with significant clinical utility, will be measured: Calprotectin (CPc) and Intact Parathyroid Hormone (PTHi). The concentrations of these two molecules vary greatly depending on pre-analytical conditions, making them very useful markers for assessing the quality of samples subjected to the lyophilization process as a long-term storage method compared to cryopreservation at -80\u00b0C.\n<\/div><br>\n<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-alpha-channel-opacity has-background is-style-dots\" style=\"background-color:#2817a3;color:#2817a3\"\/>\n\n\n\n<div>\n<b>Title:<\/b> Metabolomic characterization of the Spanish population through the analysis of urine and serum samples.<br>\n\n<b>Aim:<\/b> Refining and improving the metabolomic profile related to metabolic syndrome, as well as prospectively analyze changes in the metabolome over time.<br>\n\n\n<div class=\"exp-col-content-holder\"><a class=\"expand-cnt-link\" href=\"#\">Details and scientific description<\/a>\n\n<div class=\"hidden-content\">\n<p class=\"hiddenContentp\">\n\n<br><b>Conducting entity:<\/b> CIC bioGUNE\/Precision Medicin &#038; Metabolism Laboratory<br>\n\n<b>Principal investigator:<\/b> Dr. \u00d3scar Millet<br>\n\n<b>Funding organization:<\/b> ELKARTEK bG21 \u201cPlataforma de medicina de Precisi\u00f3n en la Comunidad Aut\u00f3noma del Pa\u00eds Vasco. Implicaci\u00f3n y aplicaciones al estudio de las alteraciones metab\u00f3licas en COVID-19 y en S\u00edndrome Metab\u00f3lico\u201d<br><br>\n\n<div style=\"text-align: justify;\">\nMetabolic syndrome has become a global pandemic due to unhealthy lifestyle habits such as lack of exercise and high-calorie diets. Despite numerous studies to date, a clinically useful group of biomarkers has not yet been identified. The composition of the metabolome (the set of small molecules present in biological materials such as serum and urine) is also influenced by lifestyle, diseases, and diet. Therefore, studying it through techniques such as Nuclear Magnetic Resonance (NMR) can contribute to a better understanding of this disease.\n<br>\nThis project aims to refine and improve the metabolomic profile studied in a previous project and analyze its relationship with metabolic syndrome. Additionally, a prospective study will be conducted to examine changes in the metabolome of individuals over time. Serum and urine samples will be collected through the National Biobank Network, and the metabolites and lipoproteins present in these samples will be analyzed using NMR.<\/div><br>\n\n<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-alpha-channel-opacity has-background is-style-dots\" style=\"background-color:#2817a3;color:#2817a3\"\/>\n\n\n\n<div>\n<b>Title:<\/b> Standardization in flow cytometry through algorithms and prediction of CMV infection<br>\n\n<b>Aim:<\/b> Validating a prediction model that allows the classification of patients according to their CMV serology (detection of antibodies against cytomegalovirus)<br>\n\n\n<div class=\"exp-col-content-holder\"><a class=\"expand-cnt-link\" href=\"#\">Details and scientific description<\/a>\n\n<div class=\"hidden-content\">\n<p class=\"hiddenContentp\">\n\n<br><b>Conducting entity:<\/b> HUMV &#8211; Hospital Universitario de Regensburg (Alemania)<br>\n\n<b>Principal investigator:<\/b> Dr. James Hutchinson<br>\n\n<b>Funding organization:<\/b> Fondos europeos<br><br>\n\n\n<div style=\"text-align: justify;\">\nThe project aims to validate a new algorithm developed by Dr. Hutchinson's laboratory for patient classification using flow cytometry data. This algorithm has been shown effective in predicting CMV serology of patients using the \"Duraclone T cell panel\" equipment via flow cytometry. The objective is to validate this algorithm on another instrument, laboratory, and patient cohort, specifically on the Cytoflex-DH cytometer used by the requesting research group. The validation seeks to confirm the robustness and generalization of the CMV serology prediction models developed by Hutchinson's laboratory.  <\/div><br>\n\n<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-alpha-channel-opacity has-background is-style-dots\" style=\"background-color:#2817a3;color:#2817a3\"\/>\n\n\n\n<div>\n<b>Title:<\/b> Validation of circulating miRNAs in the early diagnosis of breast cancer<br>\n\n<b>Aim:<\/b> Establish new markers (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6085463\/\"target=\"_blank\">miRNAs<\/a>) in the blood for the early diagnosis of breast cancer.<br>\n\n<div class=\"exp-col-content-holder\"><a class=\"expand-cnt-link\" href=\"#\">Details and scientific description<\/a>\n\n<div class=\"hidden-content\">\n<p class=\"hiddenContentp\">\n\n<br><b>Principal investigator:<\/b> J\u00e9ssica Alonso Molero, PhD<br>\n\n<b>Funding Agency:<\/b> Marqu\u00e9s de Valdecilla Research Institute (IDIVAL)<br>\n\n<b>Funding:<\/b> 5.000 \u20ac<br>\n\n<b>Call resolution:<\/b> <a style=\"text-decoration: none;\" href=\"https:\/\/aplicacionesidival.idival.org\/ConvocatoriasPropias\/es\/Convocatorias\/VerConvocatoria?Id=1012\"target=\"_blank\">NEXT-VAL 2023: NVAL23\/03<\/a><br><br>\n<div style=\"text-align: justify;\">\nThe early diagnosis of tumors such as breast cancer is one of the main goals in the field of public health. Among the tools for early detection of breast cancer, the recommendation stands out for biennial mammography in women aged 50 to 74, although its effectiveness is a subject of debate. Currently, with the advent of Next Generation Sequencing (NGS) techniques, other screening methods based on genetic factors, such as circulating miRNAs, are being proposed. MiRNAs are small RNA molecules characterized mainly by being endogenous, non-coding, and highly stable. Additionally, they exhibit two key characteristics for diagnostic use: i) They are present in blood serum, making it a minimally invasive diagnostic technique; ii) miRNAs are tissue-specific, so different tumors show different expression profiles. Thus, when used as biomarkers, they could not only reveal the presence of a tumor but also identify the type of cancer it is. In a previous study by the Department of Preventive Medicine and Public Health at the University of Cantabria, 11 miRNAs with differential expression were found in cases of breast cancer compared to healthy controls. The main objective of this project is to analyze these miRNAs in a set of subjects from the Cantabria Cohort to verify their reproducibility and validity as a tool for the early diagnosis of breast cancer.  <\/div><br>\n\n<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-alpha-channel-opacity has-background is-style-dots\" style=\"background-color:#2817a3;color:#2817a3\"\/>\n\n\n\n<div>\n<b>Title:<\/b> Analysis of immune response in different immunizing situations during the pandemic in a prospective cohort (Cantabria Cohort). Future strategies in COVID-19.<br>\n\n<b>Aim:<\/b> Determine the duration of protection provided by vaccination against the SARS-CoV-2 virus, the causative agent of COVID-19, in participants of the Cantabria Cohort.<br>\n\n<div class=\"exp-col-content-holder\"><a class=\"expand-cnt-link\" href=\"#\">Details and scientific description<\/a>\n\n<div class=\"hidden-content\">\n<p class=\"hiddenContentp\">\n\n<br><b>Principal investigator:<\/b> Marcos L\u00f3pez Hoyos, MD, PhD\n\n<br><b>Funding Agency:<\/b> Instituto de Salud Carlos III\n\n<br><b>Funding:<\/b> 147.620 \u20ac\n\n<br><b>Call resolution:<\/b> <a style=\"text-decoration: none;\" href=\"https:\/\/firmadoc.isciii.es\/firmadoccontroller?action=download&#038;id=14\/12\/2022-083e931010\"target=\"_blank\">AES 2022: PI22\/01715<\/a><br><br>\n\n<div style=\"text-align: justify;\">\nThe objective of the study is to comprehensively characterize the immune response to SARS-CoV-2 infection in adults from the Cantabria Cohort project. This versatile cohort in Personalized Medicine comprises over 23,000 volunteers recruited in less than 2 years. Unlike clinical trials, this cohort involves a combination of various natural infection, vaccination, and reinfection scenarios to assess the duration of immunity concerning exposure to the SARS-CoV-2 virus. Studying the decline in immune response in different combinations will contribute to a better definition of vaccination strategies against the SARS-CoV-2 virus, with clear translational potential in the coming years for COVID-19 vaccination strategies. Additionally, exploring autoimmune features in COVID-19 patients and vaccinated individuals will enhance our understanding of potential long-term side effects and adverse effects resulting from SARS-CoV-2 infection and\/or vaccination, possibly contributing to the poorly defined condition known as long COVID. The findings of this project will yield crucial insights for combating SARS-CoV-2 and characterizing key aspects of immune memory. <\/div><br>\n\nMore information about the project <a href=\"https:\/\/portalinvestigacion.idival.org\/proyectos\/113428\"target=\"_blank\">here. <\/a><br>\n<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-alpha-channel-opacity has-background is-style-dots\" style=\"background-color:#2817a3;color:#2817a3\"\/>\n\n\n\n<div>\n<b>Title:<\/b> From Reactive to Predictive Medicine in NAFLD: Identification of a New Signature for Early NAFLD Progression.<br>\n\n<b>Aim:<\/b> Identifying novel inflammation markers associated with non-alcoholic fatty liver disease (NAFLD) to prevent the progression of the pathology.<br>\n\n<div class=\"exp-col-content-holder\"><a class=\"expand-cnt-link\" href=\"#\">Details and scientific description<\/a>\n\n<div class=\"hidden-content\">\n<p class=\"hiddenContentp\">\n\n<br><b>Principal investigator:<\/b> Javier Crespo, MD, PhD<br>\n\n<b>Funding Agency:<\/b> Instituto de Salud Carlos III<br>\n\n<b>Funding:<\/b> 123.178,00 \u20ac<br>\n\n<b>Call resolution:<\/b> <a style=\"text-decoration: none;\" href=\"https:\/\/firmadoc.isciii.es\/firmadoccontroller?action=download&#038;id=14\/12\/2022-083e931010\" target=\"_blank\" rel=\"noopener\">AES 2022: PI22\/01853<\/a><br><br>\n<div style=\"text-align: justify;\">\nNon-alcoholic fatty liver disease (NAFLD) is a complex and heterogeneous disorder in terms of underlying causes, presentation, progression, and prognosis. Numerous factors influence NAFLD progression, and it is considered a multisystemic condition where cardiovascular pathologies are the primary cause of disease and mortality. The advanced stage of NAFLD accentuates the scarring process in response to liver damage (fibrosis), a significant predictor of mortality in NAFLD patients. Currently, there is a need to develop new tools for predicting NAFLD progression to provide appropriate management that can reduce mortality. The ultimate goal of this project is to improve the health and quality of life of NAFLD patients. This patient-centered project aims to shift from a reactive to predictive medicine and health promotion. In this regard, the development of biomarkers capable of detecting inflammation before the fibrotic process begins will enable Precision Medicine to anticipate the development of significant liver disease. <\/div><br>\n\nMore information about the project <a href=\"https:\/\/portalinvestigacion.idival.org\/proyectos\/113430\" target=\"_blank\" rel=\"noopener\">here. <\/a><br>\n\n<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-alpha-channel-opacity has-background is-style-dots\" style=\"background-color:#2817a3;color:#2817a3\"\/>\n\n\n\n<div>\n<b>Title:<\/b> Discovering chronic inflammation biomarkers that define key stages in the Healthy-to-NASH (non-alcoholic steatohepatitis) transition to inform early prevention and treatment strategies <br>\n\n<b>Aim:<\/b> Identifying new inflammation markers in advanced non-alcoholic steatohepatitis (NASH) to enhance the management of this pathology in participants of the Cantabria Cohort.<br>\n\n<div class=\"exp-col-content-holder\"><a class=\"expand-cnt-link\" href=\"#\">Details and scientific description<\/a>\n\n<div class=\"hidden-content\">\n<p class=\"hiddenContentp\">\n\n<br><b>Funding Agency:<\/b> European Commission (HORIZON Programme)<br>\n\n<b>Funding:<\/b> 6.348.927,28 \u20ac<br>\n\n<b>Call resolution:<\/b> <a style=\"text-decoration: none;\" href=\"https:\/\/ec.europa.eu\/info\/funding-tenders\/opportunities\/portal\/screen\/how-to-participate\/org-details\/993640065\/project\/101095679\/program\/43108390\/details\" target=\"_blank\" rel=\"noopener\">Proyecto Halt-RONIN<\/a><br><br>\n\n<div style=\"text-align: justify;\">\nNon-alcoholic fatty liver disease is a chronic multifactorial condition affecting 1 in 4 individuals, representing a significant personal, socioeconomic, and healthcare burden, particularly in the advanced and severe stages of the disease. Despite its substantial negative impact on society, this pathology remains challenging to diagnose and treat. Therefore, this project aims to uncover early triggers of the disease and its progression mechanisms to enhance existing detection methods, formulate plans to disseminate new personalized intervention strategies, and discover novel drugs. This approach will equip healthcare professionals with the tools and knowledge needed for diagnosis, prevention, and treatment guidelines. In the long term, the project seeks to reduce the number of patients with severe forms of the disease and provide strategies to improve patient outcomes. Researchers from various Spanish and European institutions collaborate on this project, with the Cantabria Cohort providing pseudo-anonymized clinical data and biological samples to the responsible investigators. <br><br>\n<b>. <\/b><i>_<\/i> <\/div><br>\n\nMore information about the project <a href=\"https:\/\/portalinvestigacion.idival.org\/proyectos\/113536\" target=\"_blank\" rel=\"noopener\">here. <\/a><br>\n\n<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-alpha-channel-opacity has-background is-style-dots\" style=\"background-color:#2817a3;color:#2817a3\"\/>\n\n\n\n<div>\n<b>Title:<\/b> Prevalence and Characterization of ACOX2 Deficiency-Associated Hypertransaminasemia (HADA) in the Cantabria Population. ANJANA Project.<br>\n\n<b>Aim:<\/b> Determine the prevalence of HADA, a rare genetic disorder, among participants in the Cantabria Cohort.<br>\n\n\n<div class=\"exp-col-content-holder\"><a class=\"expand-cnt-link\" href=\"#\">Details and scientific description<\/a>\n\n<div class=\"hidden-content\">\n<p class=\"hiddenContentp\">\n\n<br><b>Principal investigator:<\/b> Marta Alonso Pe\u00f1a, PhD<br>\n\n<b>Funding Agency:<\/b> Marqu\u00e9s de Valdecilla Research Institute (IDIVAL)<br>\n\n<b>Funding:<\/b> 8.500 \u20ac<br>\n\n<b>Call resolution:<\/b> <a style=\"text-decoration: none;\" href=\"https:\/\/aplicacionesidival.idival.org\/ConvocatoriasPropias\/es\/Convocatorias\/VerConvocatoria?Id=878\" target=\"_blank\" rel=\"noopener\">Proyecto Anjana (HADA-Cantabria)(NVAL 22\/04)<\/a><br><br>\n\n<div style=\"text-align: justify;\">\nHypertransaminasemia is a common finding in routine laboratory tests and often indicates liver injury due to medication or the presence of metabolic liver disease. However, the cause of up to 15% of cases of persistent hypertransaminasemia in adults remains unknown. Acyl-CoA Oxidase 2 (ACOX2) Deficiency-Associated Hypertransaminasemia (HADA) is a recently discovered rare genetic disorder resulting from an inherited alteration. Currently, five affected families have been identified, with two residing in Cantabria. Therefore, this project, funded through the Next-Val call from IDIVAL, will investigate the prevalence of HADA-causing mutations in participants of the Cantabria Cohort with a history of recurrent hypertransaminasemia. This will aid in identifying new cases and enhance understanding of the progression, diagnosis, and treatment of this condition. Cantabria Cohort will provide responsible researchers with pseudo-anonymized clinical data and DNA samples to facilitate the genetic study.  <\/div><br>\n\nMore information about the project <a href=\"https:\/\/portalinvestigacion.idival.org\/proyectos\/113312\" target=\"_blank\" rel=\"noopener\">here. <\/a><br>\n\n<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-alpha-channel-opacity has-background is-style-dots\" style=\"background-color:#2817a3;color:#2817a3\"\/>\n\n\n\n<div>\n<b>Title:<\/b> FOCUS Project<br>\n\n<b>Aim:<\/b> Detect and, if necessary, treat hepatitis virus (B and C) and human immunodeficiency virus (HIV) infections among all participants in the Cantabria Cohort.<br>\n\n\n<div class=\"exp-col-content-holder\"><a class=\"expand-cnt-link\" href=\"#\">Details and scientific description<\/a>\n\n<div class=\"hidden-content\">\n<p class=\"hiddenContentp\">\n\n<br><b>Collaborating Company:<\/b> Gilead Sciences S.L.U.<br>\n\n<b>Funding:<\/b> 190.000 \u20ac<br>\n\n<b>Call resolution:<\/b> <a style=\"text-decoration: none;\" href=\"https:\/\/boc.cantabria.es\/boces\/verAnuncioAction.do?idAnuBlob=369528\" target=\"_blank\" rel=\"noopener\">FOCUS Project<\/a><br><br>\n\n<div style=\"text-align: justify;\">\nThe FOCUS Program, launched by the Gilead Group, is a collaborative public health initiative aimed at ultimately improving the prevention, diagnosis, and care of bloodborne virus infections. Gilead Sciences is a biopharmaceutical company that, in adherence to its commitment to health research, aims to contribute to the development of research activities, training, health promotion, and the humanization of spaces in healthcare facilities in Cantabria. This collaboration agreement with the Cantabrian Health Service is non-commercial in nature and focuses on prevention, diagnosis, and assistance through the implementation of screening tests for human immunodeficiency virus (\"HIV\"), hepatitis B virus (\"HBV\"), and hepatitis C virus (\"HCV\") in the Cantabrian population.  <\/div><br>\n\n<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>A continuaci\u00f3n, se presentan todos los proyectos de investigaci\u00f3n donde se est\u00e1n empleando datos y muestras de Cohorte Cantabria: T\u00edtulo: Depresi\u00f3n de Dif\u00edcil Tratamiento: Estudio de biomarcadores g\u00e9nicos y proteicos vinculados a la respuesta cl\u00ednica al tratamiento con Ketamina o Terapia Electroconvulsiva. Finalidad: Mejorar el conocimiento de los mecanismos neurobiol\u00f3gicos implicados en la depresi\u00f3n dif\u00edcil<a class=\"more-link\" href=\"https:\/\/cohortecantabria.com\/en\/proyectos\/\">Continue reading <span class=\"screen-reader-text\">\u00abProyectos de Investigaci\u00f3n\u00bb<\/span><\/a><\/p>","protected":false},"author":200200971,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_wpcom_ai_launchpad_about_page":false,"_wpcom_ai_launchpad_gallery_page":false,"_wpcom_ai_launchpad_contact_page":false,"_wpcom_ai_launchpad_events_page":false,"_wpcom_ai_launchpad_video_page":false,"_wpcom_ai_launchpad_portfolio_piece":false,"footnotes":""},"class_list":["post-2703","page","type-page","status-publish","hentry","entry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Proyectos de Investigaci\u00f3n - Cohorte Cantabria<\/title>\n<meta name=\"description\" content=\"Cohorte Cantabria es un estudio \u00fanico y pionero en Espa\u00f1a que permitir\u00e1 avanzar en el conocimiento de las enfermedades. 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